Methandrostenolone does not react strongly with the androgen receptor[5], instead relying on activity not mediated by the receptor for its effects. These include dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time. However, due to its mode of action, it decreases the rate of cell respiration and decreases production of red blood cells. In high doses (30 mg or more per day), side effects such as gynaecomastia, high blood pressure, acne and male pattern baldness may begin to occur. The drug causes severe masculinising effects in women even at low doses. In addition, it is metabolized into estradiol by aromatase. This means that without the administration of aromatase inhibitors such as Anastrozole or Aminoglutethimide, estrogenic effects will appear over time in men. Many users will combat the estrogenic side effects with Nolvadex or Clomid. In addition, as with other 17α-alkylated steroids, the use of methandrostenolone over extended periods of time can result in liver damage without appropriate care.

Systematic (IUPAC) name
CAS number 72-63-9
ATC code A14AA03
PubChem 6300
Chemical data
Formula C20H28O2 
Mol. mass 300.441 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half life 4.5-6 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.


Legal status

DEA Schedule III (US)

Routes Oral

Out of stock